During the mid-22nd century, a century before Captain Kirk's five-year mission, Jonathan Archer captains the United Earth ship Enterprise during the early years of Starfleet, leading up to the Earth-Romulan War and the formation of the Federation.

• Scott Bakula
• Jolene Blalock
• Connor Trinneer
• John Billingsley
• Dominic Keating
• Linda Park
• Anthony Montgomery