Nan Yan, a skilled doctor who is forced to embark on a journey in the world of immortals to save her mother. Through a series of coincidences, she forms a mystical connection called the "Spiritual Connection Seal" with the enigmatic Emperor Ji Yang, who conceals his true identity. Nan Yan is practical and down-to-earth, while Ji Yang is aloof and mysterious, embodying the essence of a true immortal. Initially, the two dislike each other, but as they investigate Nan Yan's mother's illness, they become entangled in a conspiracy within the world of immortals.

• Jing Tian
• Zhang Linghe
• Darren Chen
• Chang Long
• Qiao Zhenyu
• Fan Ming
• Gao Lu
• Huang Haibing