Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange lights to scatter, some of them aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!

• Emiri Kato
• Nami Miyahara
• Machiko Kawana
• Makiko Ohmoto
• Taiten Kusunoki
• Masashi Ebara
• Hideyuki Tanaka
• Tomoko Kaneda