The story of how one company triggered the worst drug epidemic in American history. Look into the epicenter of America's struggle with opioid addiction, from a distressed Virginia mining community, to the hallways of the DEA, and to the opulence of "one percenter" Big Pharma Manhattan.

• Michael Keaton
• Peter Sarsgaard
• Michael Stuhlbarg
• Kaitlyn Dever
• Will Poulter
• Rosario Dawson
• John Hoogenakker
• Will Chase