UFC 268: Usman vs. Covington 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on November 6, 2021, at Madison Square Garden in New York City, New York, United States. A UFC Welterweight Championship rematch between the current champion Kamaru Usman (also The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner) and former interim champion Colby Covington headlined the event.

• Ultimate Fighting Championship
• Kamaru Usman
• Colby Covington
• Rose Namajunas
• Zhang Weili
• Marlon Vera
• Frankie Edgar
• Shane Burgos
• Billy Quarantillo