Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.

• Orion Pictures
• Rosanna Arquette
• Madonna
• Aidan Quinn
• Mark Blum
• Robert Joy
• Laurie Metcalf
• Anna Thomson
• Will Patton