UFC Fight Night 185: Blaydes vs. Lewis was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on February 20, 2021 at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A heavyweight bout between Curtis Blaydes and former UFC Heavyweight Championship challenger Derrick Lewis headlined this event.

• Ultimate Fighting Championship
• Derrick Lewis
• Curtis Blaydes
• Yana Santos
• Ketlen Vieira
• Darrick Minner
• Charles Rosa
• Chris Daukaus
• Aleksei Oleinik