Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

• Newmarket Films
• Summit Entertainment
• Guy Pearce
• Carrie-Anne Moss
• Joe Pantoliano
• Mark Boone Junior
• Russ Fega
• Jorja Fox
• Stephen Tobolowsky
• Harriet Sansom Harris