Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.

• Metro-Goldwyn-Mayer
• June Allyson
• Joan Collins
• Dolores Gray
• Ann Sheridan
• Ann Miller
• Leslie Nielsen
• Jeff Richards
• Agnes Moorehead