When a cure is found to treat mutations, lines are drawn amongst the X-Men—led by Professor Charles Xavier—and the Brotherhood, a band of powerful mutants organised under Xavier's former ally, Magneto.

• The Donners' Company
• 20th Century Fox
• Hugh Jackman
• Halle Berry
• Ian McKellen
• Patrick Stewart
• Famke Janssen
• Anna Paquin
• Kelsey Grammer
• James Marsden