A pathologist experiments with a deaf-mute woman who is unable to scream to prove that humans die of fright due to an organism he names The Tingler that lives within each person on the spinal cord and is suppressed only when people scream when scared.

• Columbia Pictures
• William Castle Productions
• Vincent Price
• Philip Coolidge
• Judith Evelyn
• Darryl Hickman
• Pamela Lincoln
• Patricia Cutts
• William Castle
• Bob Gunderson