The miniseries featured James Brolin as Ronald Reagan and Judy Davis as Nancy Reagan, and covers the period in time from 1949 when Reagan was still in Hollywood, through his governorship of California until Reagan's last day in office as President in 1989.

• Judy Davis
• James Brolin
• Zeljko Ivanek
• Mary Beth Peil
• Bill Smitrovich
• Shad Hart
• Zoie Palmer
• Richard Fitzpatrick