Grand Canyon revolved around six residents from different backgrounds whose lives intertwine in modern-day Los Angeles. At the center of the film is the unlikely friendship of two men from different races and classes brought together when one finds himself in jeopardy in the other's rough neighborhood.

• 20th Century Fox
• Danny Glover
• Kevin Kline
• Steve Martin
• Mary McDonnell
• Mary-Louise Parker
• Alfre Woodard
• Jeremy Sisto
• Tina Lifford