Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.

• Parkes/Lasker productions
• Robert De Niro
• Robin Williams
• John Heard
• Julie Kavner
• Penelope Ann Miller
• Ruth Nelson
• Max von Sydow
• Anne Meara